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Invitrogen™ TLR11 Polyclonal Antibody

Product Code. 12818272
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Quantity:
100 μg
Unit Size:
100µg
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12818272 100 μg 100µg
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Product Code. 12818272 Supplier Invitrogen™ Supplier No. PA520055

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Description

Rabbit Polyclonal Antibody

A suggested positive control is RAW264.7 cell lysate. PA5-20055 can be used with blocking peptide PEP-0174.

The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLR11 does not respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. TLR11-deficient mice are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating that TLR11 may play a protective role in preventing infection of internal organs of the urogenital system.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TLR11
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Tlr11
Gene Accession No. Q6R5P0
Gene Alias Gm1365; Gm287; RGD1564460; RP23-392K10.4; Tlr11; Tlr12; Toll-like receptor 11; Toll-like receptor 12
Gene Symbols Tlr11
Host Species Rabbit
Immunogen A peptide corresponding to 15 amino acids near the carboxy terminus of mouse TLR11.
Purification Method Ion-exchange chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 239081
Target Species Mouse
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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