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Invitrogen™ Tislelizumab Humanized Recombinant Human Monoclonal Antibody
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Product Code. 17748783
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Quantity:
100 μg
Unit Size:
100µg
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17748783 100 μg 100µg
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Product Code. 17748783 Supplier Invitrogen™ Supplier No. MA542162

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Description

Human Recombinant Monoclonal Antibody

Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.

Tislelizumab (BeiGene) is a humanized monoclonal antibody that was designed to bind to the PD-1 receptor and prevent binding of PD-L1. In addition, tislelizumab was designed to minimize binding to Fc-gamma-receptors (FcyR) on macrophages. Preclinical studies found that binding to FcyR on macrophages compromises the anti-tumor activity of PD-1 antibodies through activation of antibody-dependent macrophage-mediated killing of T effector cells.
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Specifications

Antigen Tislelizumab Humanized
Applications ELISA, SDS-Page
Classification Recombinant Monoclonal
Concentration 3.3 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene Alias BGB-A317
Host Species Human
Immunogen Human PDCD1/PD1/ CD279.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG4 κ
Target Molecule Chemical
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