Invitrogen™ TIMP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA595330

Product Code. 16374595

Description

Human TIMP2 shares 98.5% amino acid (aa) sequence identity with both mouse and rat TIMP2. Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: Rat Spleen Tissue, Rat Testis Tissue, Mouse Brain Tissue, Mouse Thymus Tissue, HELA whole cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

Specifications

• Antigen: TIMP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TIMP2
• Gene Alias: Collagenase inhibitor; CSC-21K; D11Bwg1104e; DDC8; etID32613.12; fa96h09; Metalloproteinase inhibitor 2; metalloproteinase inhibitor 2a; metalloproteinase inhibitor precursor; metalloproteinase inhibitor TIMP-2; metalloproteinase-2; similar to metalloproteinase inhibitor; testicular secretory protein Li 57; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP metallopeptidase inhibitor 2a; TIMP2; Timp-2; TIMP-2 protein; timp2a; tissue inhibitor of matrix metalloproteinase-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinase 2 precursor; tissue inhibitor of metalloproteinase 2a; tissue inhibitor of metalloproteinase-2; tissue inhibitor of metalloproteinase-2 precursor; tissue inhibitor of metalloproteinases 2; tissue inhibitor of mettaloproteinase 2; wu:fa96h09; zgc:136726
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21858, 29543, 7077
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide
• Gene Accession No.: P16035, P25785, P30121
• Gene Symbols: TIMP2
• Immunogen: E.coli-derived human TIMP2 recombinant protein (Position: C27-P220).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG