Invitrogen™ Thyroid Peroxidase Recombinant Rabbit Monoclonal Antibody (JE60-40)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA550707

Product Code. 17919562

Description

Positive control: Human thyroid tissue, human thyroid carcinoma tissue. Predicted band size: 103 kDa Subcellular Location: Membrane.

Thyroid Peroxidase is a gene that encodes for a membrane-bound glycoprotein, which functions as an enzyme and plays a crucial role in the proper functioning of the thyroid gland. This protein is responsible for the iodination of tyrosine residues in thyroglobulin and the formation of phenoxy-ester between pairs of iodinated tyrosines, which leads to the production of thyroid hormones such as thyroxine and triiodothyronine. Mutations in this gene are known to cause several disorders related to thyroid hormone production, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Several transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants remains undetermined. Diseases associated with TPO include Thyroid Dyshormonogenesis 2A and Congenital Hypothyroidism.

Specifications

• Antigen: Thyroid Peroxidase
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P07202
• Gene Symbols: TPO
• Immunogen: Recombinant protein within Human Thyroid Peroxidase/TPO aa 834-933/933.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin)
• Clone: JE60-40
• Conjugate: Unconjugated
• Gene: TPO
• Gene Alias: EC 1.11.1; LOW QUALITY PROTEIN: thyroid peroxidase; MSA; TDH2A; thyroid microsomal antigen; thyroid peroxidase; thyroid peroxidase (332 AA); thyroperoxidase; TPO; TPX; TPXEC 1.11.1.8
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 7173
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid