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Thyroglobulin Antibody (6E1), Novus Biologicals™

Product Code. 18422062 Shop All Bio Techne Products
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0.1 mg
20 ug
Unit Size:
0.1mg
20µg
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18422062 20 ug 20µg
18147393 0.1 mg 0.1mg
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Product Code. 18422062 Supplier Novus Biologicals Supplier No. NBP22947120ug

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Description

Mouse Monoclonal Antibody has been used in 1 publication

Thyroglobulin Monoclonal specifically detects Thyroglobulin in Human samples. It is validated for ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Thyroglobulin
Applications Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin), SDS-Page
Classification Monoclonal
Clone 60
Concentration 0.2 mg/ml
Conjugate Unconjugated
Dilution Western Blot 0.5-1 ug/mL, Flow Cytometry 0.5-1 ug/million cells, ELISA 1-5 ug/mL for coating, Immunohistochemistry 0.5-1 ug/mL, Immunohistochemistry-Paraffin 0.5-1 ug/mL
Gene Accession No. P01266
Gene Alias AITD3TGN, TDH3, Tg, thyroglobulin
Gene Symbols TG
Host Species Mouse
Immunogen Thyroglobulin isolated from human thyroid glands was used as the immunogen for the antibody.
Molecular Weight of Antigen 660 kDa
Purification Method Protein A or G purified
Quantity 20 ug
Regulatory Status RUO
Research Discipline Cancer, Cell Biology
Primary or Secondary Primary
Gene ID (Entrez) 7038
Test Specificity Thyroglobulin is a 660kDa dimeric pre-protein with multiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
Target Species Human, Mouse, Rat
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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For Research Use Only

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