Thyroglobulin Antibody (2H11), Novus Biologicals™

Mouse Monoclonal Antibody

Brand:  Novus Biologicals NBP2-29451

Product Code. 18163732

Description

Thyroglobulin Monoclonal specifically detects Thyroglobulin in Human, Mouse, Rat samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: Thyroglobulin
• Classification: Monoclonal
• Concentration: 0.2 mg/ml
• Dilution: Flow Cytometry 0.5-1ug/million cells in 0.1ml, Immunohistochemistry-Paraffin 0.1-0.2ug/ml
• Gene Alias: AITD3TGN, TDH3, Tg, thyroglobulin
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: monoclonal antibody 2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by monoclonal antibody 6E1. Thyroglobulin is a 660kDa dimeric pre-protein with multiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
• Content And Storage: Store at 4C.
• Isotype: IgG1 κ

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin)
• Clone: 2H11
• Conjugate: Unconjugated
• Gene Accession No.: P01266
• Gene Symbols: TG
• Immunogen: Human thyroid follicular cells were used as immunogen to generate the antibody.
• Quantity: 0.1 mg
• Research Discipline: Cancer, Cell Biology
• Gene ID (Entrez): 7038
• Target Species: Human, Mouse, Rat
• Form: Purified

For Research Use Only