Thymidylate synthase Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16864024	Proteintech 15047-1-AP-20UL	20 μL
16854024	Proteintech 15047-1-AP-150UL	150 μL

Description

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Specifications

• Antigen: Thymidylate synthase
• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: P04818, P07607, P45352
• Gene ID (Entrez): 22171, 29261, 7298
• Immunogen: Thymidylate synthase Fusion Protein Ag7027
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: TYMS

• Concentration: 0.31 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: HsT422, Thymidylate synthase, thymidylate synthetase, TMS, TS, TSase, TYMS
• Gene Symbols: TYMS
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody