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Thymidylate Synthase Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA5140272

Additional Details : Weight : 0.01000kg

Product Code. 17834790

  • £353.00 / 100µL
Estimated Shipment: 19-08-2024
to see stock.

Description

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: SSKGVKIWDA NGSRDFLDSL GFSTREEGDL GPVYGFQWRH FGAEYRDMES DYSGQGVDQL QRVIDTIKTN PDD

Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Specifications

Specifications

Thymidylate Synthase
Polyclonal
Unconjugated
TYMS
HST422; MGC88736; OK/SW-cl.29; Thymidylate synthase; thymidylate synthetase; TMS; TS; Tsase; Tyms; tysy
Rabbit
Antigen affinity chromatography
RUO
7298
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry, Western Blot
0.2 μg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
P04818
TYMS
Recombinant protein corresponding to Human TYMS
100 μL
Primary
Human
Antibody
IgG
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