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Thymidylate Synthase Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA5140272
This item is not returnable.
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Description
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: SSKGVKIWDA NGSRDFLDSL GFSTREEGDL GPVYGFQWRH FGAEYRDMES DYSGQGVDQL QRVIDTIKTN PDD
Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.Specifications
Thymidylate Synthase | |
Polyclonal | |
Unconjugated | |
TYMS | |
HST422; MGC88736; OK/SW-cl.29; Thymidylate synthase; thymidylate synthetase; TMS; TS; Tsase; Tyms; tysy | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
7298 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry, Western Blot | |
0.2 μg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
P04818 | |
TYMS | |
Recombinant protein corresponding to Human TYMS | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |