ThPOK Rat anti-Mouse, PE, Clone: 2POK, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-5928-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15228919

Quantity Price
1 £ 182.82 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Isotype IgG2a
Format Conjugated
Monoclonal or Polyclonal Monoclonal
Quantity 100μg
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry (Intracellular Staining)
Host Species Rat
Regulatory Status RUO
Primary or Secondary Primary
Species Reactivity Mouse
Gene Alias c-Krox, Zbtb7b
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone 2POK
Antigen ThPOK
Concentration 0.2mg/mL
Conjugate PE

This 2POK monoclonal antibody reacts with mouse ThPOK, which is also known as c-Krox and Zbtb7b. In hematopoietic cells, this 78kDa transcription factor is expressed in thymocytes and T lymphocytes in the spleen and lymph nodes. In non-hematopoietic cells, ThPOK can be detected in the skin, heart, smooth muscle, and liver. Studies demonstrate that ThPOK promotes CD4+ lineage differentiation by inhibiting the expression of CD8 lineage-specific genes such as Runx3. ThPOK has also been shown to inhibit Cd4 silencing, another key facet required for differentiation to the CD4+ lineage. In addition to its role in thymocyte development, ThPOK is involved in the effector functions of invariant natural killer T (iNKT) cells and gamma delta T cells.