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Invitrogen™ Human BACE2 (aa 503-518) Synthetic Peptide

Synthetic Peptide

Brand:  Invitrogen™ PEP167

Code : LE

Additional Details : CAS Number : 69-74-9 Weight : 0.01000kg

Product Code. 11574820

  • £154.00 / 50µg
Estimated Shipment: 15-04-2024
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Description

Description

Human BACE2 (residues 503-518) Synthetic Peptide, PEP-167, from Invitrogen.

BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients. PEP-167 is a 17 amino acid synthetic peptide whose sequence is derived from human BACE2 protein. The sequence of this peptide is (amino to carboxy terminus): C-P (503)-E-V-V-N-D-E-S-S-L-V-R-H-R-W-K (518)This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human BACE2, catalog &Num; PA1-754. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (∽70-fold) for competitive inhibition of antibody-protein binding reactions.Reconstitute with 0.1 mL of distilled water.
Specifications

Specifications

25825
purified
Human BACE2 (aa 503-518)
-20°C. Avoid freeze-thaw cycles.
Lyophilized
Control
Yes
Peptide
RUO - research use only
Human
Q9Y5Z0
0.5 mg/mL
Synthetic Peptide
peptide with no preservative
BACE2
No preservative
50 μg
C-P(503)-E-V-V-N-D-E-S-S-L-V-R-H-R-W-K(518)
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