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Invitrogen™ Human CD25 (IL-2R alpha) Recombinant Protein

Recombinant Protein

Brand:  Invitrogen™ RP75591

Code : LD

Additional Details : CAS Number : 69-74-9 Weight : 0.01000kg

Product Code. 11508921

  • £722.00 / 100µg
Estimated Shipment: 23-04-2024
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Description

Description

IL-2 Receptor alpha (human) Recombinant Protein, RP-75591, from Invitrogen.

CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. This product contains purified recombinant human IL-2 Receptor alpha protein with an N-terminal hexahistidine tag. This product may be used as a positive control in many immunological assays.
Specifications

Specifications

P01589
PBS with 50% glycerol and no preservative; pH 7.4
Human CD25
100μg
N/A
RUO
IL2RA
Unconjugated
E. coli
Liquid
purified
Control, Western Blot
3559
7.4
E. coli
-20°C, Avoid Freeze/Thaw Cycles
Human CD25
Human
Hu
Recombinant
Recombinant
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