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  5. Tocris™ TH 5487

Tocris™ TH 5487
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Product Code. 18778626
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18778626

Brand: Tocris™ 6749/50

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Description

Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor

TH 5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 342 nM). Selective for OGG1 over other base excision repair enzymes. Inhibits OGG1 binding to 8-oxoG in DNA and suppresses proinflammatory gene expression in TNF-α stimulated lung epithelial cells in vitro. Also inhibits proinflamatory gene expression and neutrophil recruitment in TNF-α-challenged mouse lungs in vivo.
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Specifications

Quantity 50 mg
Molecular Formula C19H18BrIN4O2
Formula Weight 541.18
Product Type Inhibitor
Purity 98%
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