Invitrogen™ TGM2 Monoclonal Antibody (CUB 7402)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA512739

Product Code. 11364703

Description

MA5-12739 targets Transglutaminase II in IF, IHC (P), IP, and WB applications and shows reactivity with Canine, Guinea Pig, Human, and Rabbit samples. The MA5-12739 immunogen is purified guinea pig liver TGase II.

Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.

Specifications

• Antigen: TGM2
• Classification: Monoclonal
• Concentration: 0.02 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Gene Accession No.: P08587, P21980
• Gene Symbols: TGM2
• Immunogen: Purified guinea pig liver TGase II.
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Canine, Guinea Pig, Human, Rabbit
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: CUB 7402
• Conjugate: Unconjugated
• Gene: TGM2
• Gene Alias: C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; G alpha h; G[a]h; G-ALPHA-h; GNAH; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine-gamma-glutamyltransferase; RP5-1054A22.2; TG C; TG(C); TG2; TGase C; TGase H; TGase2; TGase-2; TGase-H; TgaseII; TGC; TGM2; Tissue transglutaminase; Tissue type transglutaminase; tissue-type transglutaminase; transglutaminase; transglutaminase 2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Transglutaminase 2 C polypeptide; transglutaminase 2, C polypeptide; transglutaminase C; Transglutaminase H; transglutaminase-2; tTG; tTGas
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 100352148, 100379228, 485867, 7052
• Content And Storage: 4°C
• Form: Liquid