PeproTech TGF beta-1 Monoclonal Antibody, PeproTech®

Mouse Monoclonal Antibody

Brand:  PeproTech 500-M66-500UG

Product Code. 17864783

Description

AA Sequence of recombinant protein: discontinued. Preparation: Produced in BALB/c mice immunized with highly pure Recombinant Human TGF-beta1. Anti-Human TGF-beta1-specific antibody was purified from tissue culture supernatant by Protein G affinity chromatography. Western Blot: To detect Human TGF-beta1 by Western Blot analysis this antibody can be used at a concentration of 2.0-4.0 μg/mL. When used in conjunction with compatible secondary reagents the detection limit for Recombinant Human TGF-beta1 is 0.25-0.50 ng/lane, under reducing and non-reducing conditions.

TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.

Specifications

• Antigen: TGF beta-1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: Tgfb1
• Gene Alias: CED; cytokine; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; TGF b; TGF b 1; TGF beta; tgf beta 1; tgf beta1; TGF beta-1; TGF beta-1 protein; TGF β; TGF β 1; TGF β1; Tgfb; TGFB1; TGF-B1; Tgfb-1; TGFbeta; TGF-beta 1; TGF-beta 1 protein; TGFbeta1; TGF-beta1; TGF-beta-1; TGFβ1; Transforming growth factor; transforming growth factor b1; transforming growth factor beta; transforming growth factor beta 1; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor beta-1 proprotein; transforming growth factor beta-1; transforming growth factor β1; transforming growth factor, beta 1; transforming growth factor, beta 1 (Camurati-Engelmann disease); transforming growth factor, beta-1; transforming growth factor-beta 1; transforming growth factor-beta I; transforming growth factor-beta-1; transforming growth factor-beta-1 precursor; unnamed protein product
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 7040
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P01137
• Gene Symbols: Tgfb1
• Immunogen: Insect cells-derived Recombinant Human TGF-beta1.
• Quantity: 500 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody