Invitrogen™ TFPI Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA588707

Product Code. 16546851

Description

Immunogen sequence: DSEEDEEHTI ITDTELPPLK LMHSFCAFKA DDGPCKAIMK RFFFNIFTRQ CEEFIYGGCE GNQNRFESLE ECKKMCTRDN ANRIIKTTLQ QEKPDFCFLE EDPGICRGYI TRYFYNNQTK QCERFKYGGC LGNMNNFETL EECKNICEDG PNGFQVDNYG TQLNAVNNSL TPQSTKVPSL FVTKEGTNDG WKNAAH; Positive Samples: MCF-7, Mouse spleen, Rat lung; Cellular Location: GPI-anchor, Lipid-anchor, Microsome membrane.

Tissue factor pathway inhibitor (TFPI), also known as lipoprotein-associated coagulation inhibitor, is a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. TFPI is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop.

Specifications

• Antigen: TFPI
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TFPI
• Gene Alias: A630013F22Rik; anti-convertin; AW552122; EPI; Extrinsic pathway inhibitor; LACI; Lipoprotein-associated coagulation inhibitor; OTTHUMP00000163472; OTTHUMP00000205431; TFI; TFPI; TFPI1; Tissue factor pathway inhibitor; tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21788, 29436, 7035
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.89 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O54819, P10646, Q02445
• Gene Symbols: TFPI
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 29-224 of human TFPI (NP_0010274521).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG