Invitrogen™ Teprotumumab Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA558639

Product Code. 30283084

Description

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

Teprotumumab is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor. 8 Following a clinical trial in which its efficacy in the treatment of thyroid eye disease (TED) was assessed, it received breakthrough therapy designation from the FDA in 20163 and was approved by the FDA in January 2020 for the treatment of TED. 7 Thyroid eye disease is a potentially debilitating complication of Graves' Disease involving inflammation and tissue remodeling behind the eye, and previous treatment options typically involved multiple invasive surgeries - teprotumumab is the first pharmaceutical ever approved for the treatment of TED and therefore represents a significant step forward in the treatment this disease.

Specifications

• Antigen: Teprotumumab
• Classification: Recombinant Monoclonal
• Conjugate: Unconjugated
• Gene Alias: RO4858696-000
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Flow Cytometry, Functional Assay, Surface Plasmon Resonance
• Concentration: 1 mg/mL
• Formulation: 25mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2
• Host Species: Human
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized