Learn More
TEM8 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA1602
Code : LE
Additional Details : Weight : 0.01000kg
Description
PA1-602 detects Tem-8 from mouse samples. PA1-602 has been successfully used in Western blot and immunohistochemical procedures. By Western blot, this antibody detects ∽45 kDa, 60 kDa, 85 kDa proteins, representing Tem-8 from mouse tissue extracts.This antibody has also been used in immunohistochemical procedures (paraffin samples) using mouse tissues. PA1-602 immunizing peptide corresponds to amino acid residues 92-107, within the extracellular domain, of human ATR/TEM8. This peptide (Cat. # PEP-253) is available for neutralization and control experiments.
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.Specifications
TEM8 | |
Polyclonal | |
Unconjugated | |
ANTXR1 | |
2310008J16Rik; 2810405N18Rik; anthrax toxin receptor; anthrax toxin receptor 1; Antrx1; ANTXR1; ATR; FLJ10601; FLJ11298; FLJ21776; GAPO; TEM8; Tem-8; tumor endothelial marker 8 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
69538, 84168 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
PBS with 1mg/mL BSA and 0.05% sodium azide | |
Q9CZ52, Q9H6X2 | |
ANTXR1 | |
Synthetic Peptide: L(92) M K L T E D R E Q I R Q G L E(107) C | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |