Invitrogen™ TDRD6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5140337

Product Code. 17884850

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: INSSYKELKL LQSLTKTNLV TQYQDSVGNK NSQVFPLTTE KKEEISAETP LKTARVEATL SERKIGDSCD KDLPLKFCEF PQKTI Highest antigen sequence indentity to the following orthologs: Rat - 53%, Mouse - 54%.

Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation. Essential for RNA-dependent helicase UPF1 localization to chromatoid body, for UPF1-UPF2 and UPF1-DDX4 interactions which are required for mRNA degradation, using the extended 3' UTR-triggered nonsense-mediated mRNA decay (NMD) pathway. Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through interaction with arginine N-methyltransferase PRMT5 and symmetrically arginine dimethylated SNRPB (small nuclear ribonucleoprotein-associated protein).

Specifications

• Antigen: TDRD6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TDRD6
• Gene Alias: SPATA36; Tudor Domain Containing 6
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 221400
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O60522
• Gene Symbols: TDRD6
• Immunogen: Recombinant protein corresponding to Human TDRD6. Recombinant protein control fragment (Product #RP-109513).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG