TDP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16897143	Proteintech 10641-1-AP-20UL	20 μL
16887143	Proteintech 10641-1-AP-150UL	150 μL

Description

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Specifications

• Antigen: TDP1
• Applications: Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse, Rat, Human
• Gene Accession No.: Q4G056, Q8BJ37, Q9NUW8
• Gene ID (Entrez): 104884, 314380, 55775
• Immunogen: TDP1 Fusion Protein Ag0964
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: TDP1

• Concentration: 0.13 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: TDP1, Tyr DNA phosphodiesterase 1
• Gene Symbols: Tdp1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody