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Invitrogen™ TDP-43 Polyclonal Antibody

Product Code. 12848592
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Quantity:
100 μg
Unit Size:
100µg
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12848592 100 μg 100µg
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Product Code. 12848592 Supplier Invitrogen™ Supplier No. PA520408

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Description

Rabbit Polyclonal Antibody

A suggested positive control is Hela cell lysate. PA5-20408 can be used with blocking peptide PEP-0525. The immunogen is located within amino acids 60 - 110 of TDP43.

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TDP-43
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TARDBP
Gene Accession No. Q13148, Q921F2
Gene Alias 1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg
Gene Symbols TARDBP
Host Species Rabbit
Immunogen A 15 amino acid synthetic peptide from near the amino terminus of human TDP43.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 230908, 23435, 298648
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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