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TDP-43 Monoclonal Antibody (3H8), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA547420

Additional Details : Weight : 0.01000kg

Product Code. 17836397

  • £393.00 / 100µL
Estimated Shipment: 19-08-2024
to see stock.

Description

Description

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"e;e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.
Specifications

Specifications

TDP-43
Monoclonal
1 mg/mL
PBS with 50% glycerol and 5mM sodium azide
Q13148, Q921F2
TARDBP
Full length recombinant human TDP43 expressed in and purified from E. coli.
100 μL
Primary
Bovine, Equine, Human, Mouse, Porcine, Rat
Antibody
IgG1
Immunocytochemistry, Immunohistochemistry (PFA fixed), Western Blot
3H8
Unconjugated
TARDBP
1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg
Mouse
Protein A/G
RUO
100051482, 100739753, 230908, 23435, 298648, 540632
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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