TDP-43 Monoclonal Antibody (3H8), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA547420

Product Code. 17836397

Description

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"e;e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.

Specifications

• Antigen: TDP-43
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 5mM sodium azide
• Gene Accession No.: Q13148, Q921F2
• Gene Symbols: TARDBP
• Immunogen: Full length recombinant human TDP43 expressed in and purified from E. coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Bovine, Equine, Human, Mouse, Porcine, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunocytochemistry, Immunohistochemistry (PFA fixed), Western Blot
• Clone: 3H8
• Conjugate: Unconjugated
• Gene: TARDBP
• Gene Alias: 1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 100051482, 100739753, 230908, 23435, 298648, 540632
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid