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Invitrogen™ TDG Polyclonal Antibody
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Product Code. 16579251
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Quantity:
100 μL
Unit Size:
100µL
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16579251 100 μL 100µL
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Product Code. 16579251 Supplier Invitrogen™ Supplier No. PA596415

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Description

Rabbit Polyclonal Antibody

Positive Samples: HT-29, MCF7, HL-60, Mouse stomach, rat eye, rat stomach; Cellular Location: Nucleus Immunogen sequence: MEAENAGSYS LQQAQAFYTF PFQQLMAEAP NMAVVNEQQM PEEVPAPAPA QEPVQEAPKG RKRKPRTTEP KQPVEPKKPV ESKKSGKSAK SKEKQEKITD TFKVKRKVDR FNGVSEAELL TKTLPDILTF NLDIVIIGIN PGLMAAYKGH HYPGPGNHFW.

The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mis paired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TDG
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene TDG
Gene Accession No. P56581, Q13569
Gene Alias C-JUN leucine zipper interactive protein JZA-3; E130317C12Rik; G/T mismatch-specific thymine DNA glycosylase; hTDG; Jza1; JZA-3; Tdg; thymine DNA glycosylase; thymine-DNA glycosylase
Gene Symbols TDG
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human TDG (NP_0032023).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114521, 21665, 6996
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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