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Invitrogen™ TCTN3 Polyclonal Antibody

Product Code. 12839132
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Quantity:
100 μg
Unit Size:
100µg
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12839132 100 μg 100µg
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Product Code. 12839132 Supplier Invitrogen™ Supplier No. PA520985

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Description

Rabbit Polyclonal Antibody

A suggested positive control is SK-N-SH cell lysate. PA5-20985 can be used with blocking peptide PEP-1099.

TCTN3 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN3 is not known, it is 58% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCTN3
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TCTN3
Gene Accession No. Q6NUS6, Q8R2Q6
Gene Alias 4930521E07Rik; AI197391; C10orf61; JBTS18; OFD4; PSEC0041; RGD1305166; RP11-7D5.3; TCTN3; Tect3; tectonic 3; tectonic family member 3; tectonic-3; UNQ1881/PRO4324
Gene Symbols TCTN3
Host Species Rabbit
Immunogen A 17 amino acid peptide near the carboxy terminus of human TCTN3.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26123, 309486, 67590
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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