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Invitrogen™ TCTN2 Polyclonal Antibody

Product Code. 12829132
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Quantity:
100 μg
Unit Size:
100µg
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12829132 100 μg 100µg
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Product Code. 12829132 Supplier Invitrogen™ Supplier No. PA520984

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Description

Rabbit Polyclonal Antibody

A suggested positive control is SK-N-SH cell lysate. PA5-20984 can be used with blocking peptide PEP-1098.

TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not known, it is 49% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13. 5 and E16. 5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCTN2
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TCTN2
Gene Accession No. Q2MV57, Q96GX1
Gene Alias 4432405B04Rik; C12orf38; JBTS24; MKS8; Tctn2; TECT2; tectonic 2; tectonic family member 2; tectonic-2
Gene Symbols TCTN2
Host Species Rabbit
Immunogen A 15 amino acid peptide near the carboxy terminus of human TCTN2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 67978, 79867
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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