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Invitrogen™ TCTN1 Polyclonal Antibody

Product Code. 12819132
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Quantity:
100 μg
Unit Size:
100µg
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12819132 100 μg 100µg
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Product Code. 12819132 Supplier Invitrogen™ Supplier No. PA520983

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Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse kidney tissue lysate. PA5-20983 can be used with blocking peptide PEP-1097.

TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13. 5 and E16. 5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCTN1
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TCTN1
Gene Accession No. Q2MV58, Q8BZ64
Gene Alias G730031O11Rik; JBTS13; RGD1566266; TCTN1; TECT1; tectonic family member 1; tectonic-1; UNQ9369/PRO34160
Gene Symbols TCTN1
Host Species Rabbit
Immunogen A 15 amino acid peptide near the amino terminus of human TCTN1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 654470, 79600
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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