Invitrogen™ TCTN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA558883

Product Code. 15786751

Description

Immunogen sequence: VPLSGNPGYV VGLPLAAGFQ PHKGSGIIQT TNRYGQLTIL HSTTEQDCLA LEGVRTPVLF GYTMQSGCKL RLTGALPCQL VAQ Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 80%.

TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13. 5 and E16. 5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.

Specifications

• Antigen: TCTN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TCTN1
• Gene Alias: G730031O11Rik; JBTS13; RGD1566266; TCTN1; TECT1; tectonic family member 1; tectonic-1; UNQ9369/PRO34160
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79600
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q2MV58
• Gene Symbols: TCTN1
• Immunogen: Recombinant protein corresponding to Human TCTN1. Recombinant protein control fragment (Product #RP-97901).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG