Invitrogen™ TCR delta Monoclonal Antibody (TS-1)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ TCR1055

Product Code. 11868821

Description

TCR1055 targets TCR Delta TCS1 in FACS, IHC(F), IP, and TCA applications and shows reactivity with Human samples. The TCR1055 immunogen is human TCR Vdelta1-Jdelta1. TCR1055 detects TCR Delta TCS1 which has a predicted molecular weight of approximately 17 kDa.

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Specifications

• Antigen: TCR delta
• Classification: Monoclonal
• Concentration: 0.15 mg/mL
• Formulation: PBS with 0.5% BSA and 0.1% sodium azide
• Gene Accession No.: A0A1B0GX56
• Gene Symbols: TRD, TRDV1
• Immunogen: Human TCR Vdelta1-Jdelta1.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, T-Cell Activation
• Clone: TS-1
• Conjugate: Unconjugated
• Gene: TRDV1
• Gene Alias: CD3 antigen; CD3d antigen; OKT3
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 28518, 6964
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Green Features: Responsibly packaged

Safety and Handling

Product Identifier

• TCR delta Monoclonal Antibody (TS-1)

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4

Hazard Statement

• H302-Harmful if swallowed.

Precautionary Statement

• P260-Do not breathe dust/fume/gas/mist/vapours/spray.
• P264-Wash hands thoroughly after handling.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : sodium azide