Invitrogen™ TCR delta Monoclonal Antibody (TS-1), FITC

Mouse Monoclonal Antibody

Brand:  Invitrogen™ TCR2055

Product Code. 10699034

Description

TCR2055 targets TCR Delta TCS1 in FACS applications and shows reactivity with Human samples. The TCR2055 immunogen is human TCR Vdelta1-Jdelta2. TCR2055 detects TCR Delta TCS1 which has a predicted molecular weight of approximately 127 kDa. Washing step with 0.1% Tween is necessary to expose antigen.

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Specifications

• Antigen: TCR delta
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 0.5% BSA and 0.1% sodium azide
• Gene Accession No.: A0A1B0GX56
• Gene Symbols: TRD, TRDV1
• Immunogen: Human TCR Vdelta1-Jdelta2.
• Quantity: 200 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry
• Clone: TS-1
• Conjugate: FITC
• Gene: TRDV1
• Gene Alias: CD3 antigen; CD3d antigen; OKT3
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 28518, 6964
• Content And Storage: 4°C, store in dark
• Form: Liquid