TCOF1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16827773	Proteintech 11003-1-AP-20UL	20 μL
16817773	Proteintech 11003-1-AP-150UL	150 μL

Description

Treacle is a serine/alanine-rich 1,411 amino acid nuclear phosphoprotein that interacts with upstream binding factor (UBF) and affects transcription of the ribosomal DNA gene. Treacle is also involved in early embryonic development, particularly in the craniofacial complex, and may play a role in nucleolarcytoplasmic transport. The Treacle protein contains three domains with unique N- and C-termini and a large central repeat domain. Mutations in TCOF1, the gene that encodes for Treacle, cause Treacher Collins-Franceschetti syndrome (TCS), a disorder characterized by defects in craniofacial development. Symptoms of TCS include conductive hearing loss, hypoplasia of the mandible and maxilla, downward sloping palpebral fissures and cleft palate.

Specifications

• Antigen: TCOF1
• Applications: Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse, Human
• Gene Accession No.: O08784, Q13428
• Gene ID (Entrez): 21453, 6949
• Immunogen: TCOF1 Fusion Protein Ag1447
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: TCOF1

• Concentration: 0.3 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: MFD1, TCOF1, treacle, Treacle protein
• Gene Symbols: TCOF1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody