Invitrogen™ TCIRG1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA590425

Product Code. 16527831

Description

Immunogen sequence: MGSMFRSEEV ALVQLFLPTA AAYTCVSRLG ELGLVEFRDL NASVSAFQRR FVVDVRRCEE LEKTFTFLQE EVRRAGLVLP PPKGRLPAPP PRDLLRIQEE TERLAQELRD VRGNQQALRA QLHQLQLHAA; Positive Samples: U2OS, A-549, BxPC-3, U-937, HL-60, Mouse thymus, Mouse skeletal muscle, Rat thymus, Rat skeletal muscle; Cellular Location: Membrane, Multi-pass membrane protein.

The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.

Specifications

• Antigen: TCIRG1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TCIRG1
• Gene Alias: a3; ATP6a3; Atp6i; ATP6N1C; ATP6V0A3; ATPase, H+ transporting, 116kD; ATPase, H+ transporting, lysosomal I; ATPase, H+ transporting, lysosomal V0 protein a; oc; OC116; OC-116; OC-116 kDa; OC-116kDa; OPTB1; osteoclastic proton pump; osteoclastic proton pump 116 kDa subunit; osteosclerotic; specific 116-kDa vacuolar proton pump subunit; Stv1; T cell immune response cDNA7 protein; T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; T-cell immune regulator 1; T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3; T-cell immune response cDNA 7; T-cell immune response cDNA7 protein; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3; TCIRG1; TIRC7; vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3; V-ATPase 116 kDa isoform a3; V-ATPase 116-kDa; V-ATPase a3; v-H+ATPase subunit a3; Vph1; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a isoform 3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10312, 27060, 293650
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 2.22 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: Q13488
• Gene Symbols: TCIRG1
• Immunogen: Recombinant protein (or fragment).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG