Invitrogen™ TCF7L2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA578192

Product Code. 16376894

Description

Positive Control: 293T, A431, HeLa, HepG2 Predicted Reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Bovine (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.

Specifications

• Antigen: TCF7L2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tcf7l2
• Gene Alias: HMG box transcription factor 4; hTCF; hTCF 4; hTCF-4; mTCF-4; mTcf-4B; mTcf-4E; RP11-357H24.1; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant F; T-cell factor-4 variant G; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; T-cell-specific transcription factor 4; TCF 4; TCF4; TCF-4; TCF4B; TCF4E; Tcf7l2; TCF7L2 protein; transcription factor 7 like 2; transcription factor 7 like 2, T cell specific, HMG box; transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box; transcription factor Tcf4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21416, 679869, 6934
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1.91 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q924A0, Q9NQB0
• Gene Symbols: Tcf7l2
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human TCF7L2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG