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TBK1 Monoclonal Antibody (A8D10), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen MA544942
This item is not returnable.
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Description
TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling. TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKK beta, and IKKK. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K. NAK/TBK1 activates IKK beta through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.
Specifications
| TBK1 | |
| Monoclonal | |
| 2 mg/mL | |
| PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4 | |
| Q9UHD2, Q9WUN2 | |
| TBK1 | |
| Recombinant protein within human TBK1 aa 530-729/729. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Liquid |
| Western Blot | |
| A8D10 | |
| Unconjugated | |
| TBK1 | |
| 1200008B05Rik; AI462036; AW048562; FLJ11330; FTDALS4; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine protein kinase TBK1; serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; tbk; TBK1 | |
| Mouse | |
| Protein A | |
| RUO | |
| 29110, 299827, 56480 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| IgG1 |