missing translation for 'onlineSavingsMsg'
Learn More

TBK1 Monoclonal Antibody (A8D10), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA544942

Additional Details : Weight : 0.01000kg

Product Code. 17830266

  • £383.00 / 100µL
Estimated Shipment: 23-08-2024
to see stock.

Description

Description

TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling. TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKK beta, and IKKK. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K. NAK/TBK1 activates IKK beta through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.
Specifications

Specifications

TBK1
Monoclonal
2 mg/mL
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Q9UHD2, Q9WUN2
TBK1
Recombinant protein within human TBK1 aa 530-729/729.
100 μL
Primary
Human, Mouse, Rat
Liquid
Western Blot
A8D10
Unconjugated
TBK1
1200008B05Rik; AI462036; AW048562; FLJ11330; FTDALS4; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine protein kinase TBK1; serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; tbk; TBK1
Mouse
Protein A
RUO
29110, 299827, 56480
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
IgG1
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers