TAS0728, MedChemExpress

Product Code.	Quantity	unitSize
16427217	5 mg	5mg
16420807	50 mg	50mg
16415366	100 mg	100mg
16404498	10 mg	10mg

Product Code. 16427217 Supplier Medchem Express Supplier No. HY1115535mg

Description

MedChemExpress TAS0728 is a potent, selective, orally active, irreversible and covalent-binding HER2 inhibitor, with an IC50 of 13 nM. TAS0728 also shows IC50s of 4.9, 8.5, 31, 65, 33, 25 and 86 nM for BMX、HER4、BLK、EGFR、JAK3、SLK and LOK respectively. Furthermore, TAS0728 exhibits robust and sustained inhibition of the phosphorylation of HER2HER3, and downstream effectors.

TAS0728 is a potent, selective, orally active, irreversible and covalent-binding HER2 inhibitor, with an IC50 of 13 nM. TAS0728 also shows IC50s of 4.9, 8.5, 31, 65, 33, 25 and 86 nM for BMX、HER4、BLK、EGFR、JAK3、SLK and LOK respectively. Furthermore, TAS0728 exhibits robust and sustained inhibition of the phosphorylation of HER2HER3, and downstream effectors.

Specifications

• Chemical Name or Material: TAS0728
• CAS: 2088323-16-2
• Color: White
• Purity Grade Notes: Research
• Molecular Formula: C₂₆H₃₂N₈O₃
• Quantity: 5 mg
• Solubility Information: DMSO : 125 mg/mL (247.73 mM; Need ultrasonic)
• SMILES: NC1=C2C(N([C@H]3CN(C(C=C)=O)CCC3)N=C2C(NC4=CC=C(CC(N(C)C)=O)C(C)=C4C)=O)=NC=N1
• Molecular Weight (g/mol): 504.58
• Formula Weight: 504.58
• Percent Purity: 99.05%
• Grade: Research
• Physical Form: Solid
• For Use With (Application): Cancer-Kinase/protease

Research purposes only