Invitrogen™ TAP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA551558

Product Code. 15789510

Description

Immunogen sequence: GSGKSTVAAL LQNLYQPTGG QVLLDEKPIS QYEHCYLHSQ VVSVGQEPVL FSGSVRNNIA YGLQSCEDDK VMAAAQAAHA DDFIQEMEHG IYTDVGEKGS QLAAGQKQRL AIARALVRDP RVLILDEATS ALDVQCEQA Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 81%.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.

Specifications

• Antigen: TAP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TAP2
• Gene Alias: ABC transporter, MHC 2; ABC18; ABCB3; AI462429; Antigen peptide transporter 2; APT2; ATP dependent transport protein family member; ATP-binding cassette sub-family B member 3; ATP-binding cassette, sub-family B (MDR/TAP), member 3; Cim; D6S217E; Ham2; Ham-2; Histocompatibility antigen modifier 2; jas; MTP2; Peptide supply factor 2; peptide transporter involved in antigen processing 2; Peptide transporter PSF2; Peptide transporter TAP2; PSF2; PSF-2; Really interesting new gene 11 protein; RING11; TAP2; Tap-2; Transporter 2 ABC (ATP binding cassette); transporter 2 ATP-binding cassette sub-family B; transporter 2, ABC (ATP binding cassette); transporter 2, ATP binding cassette subfamily B member; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); Y1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6891
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q03519
• Gene Symbols: TAP2
• Immunogen: Recombinant protein corresponding to Human TAP2. Recombinant protein control fragment (Product #RP-95379).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG