Invitrogen™ Talin 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA580133

Product Code. 15965695

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human Hela whole cell, human HepG2 whole cell, human Jurkat whole cell, rat C6 whole cell, mouse NIH/3T3 whole cell. IHC: human Lung cancer tissue, mouse small intestine tissue, human intestinal cancer tissue, human tonsil tissue, rat small intestine tissue, rat lung tissue, rat spleen tissue, mouse spleen tissue.

Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-235 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin.

Specifications

• Antigen: Talin 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TLN1
• Gene Alias: ILWEQ; KIAA1027; talin 1; talin-1; TLN; TLN1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21894, 313494, 7094
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and 0.05mg sodium azide
• Gene Accession No.: P26039, Q9Y490
• Gene Symbols: TLN1
• Immunogen: A synthetic peptide corresponding to a sequence of human Talin 1 (QQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQ).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG