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Tocris™ Takinib
Potent and selective TAK1/MAP3K7 kinase inhibitor
£85.00 - £300.00
Specifications
| Chemical Name or Material | N1-(1-Propyl-1 H-benzimidazol-2-yl)-1,3-benzenedicarboxamide |
|---|---|
| CAS | 1111556-37-6 |
| Target | Other Kinase Inhibitors |
| Molecular Formula | C18H18N4O2 |
| Purity | 0.98 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18708756
|
Tocris™
6430/25 |
25 mg |
£300.00
25mg |
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|
18778356
|
Tocris™
6430/5 |
5 mg |
£85.00
5mg |
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Description
Takinib is a potent and selective TAK1/MAP3K7 kinase inhibitor (IC50 = 8.2-9.5 nM). Selective for TAK1 over IRAK4, IRAK1, GCK, CLK2 and MINK1 (IC50 values = 120, 390, 430, 430 and 1900 nM, respectively). Demonstrates weak inhibition at Src and Yes1. Exhibits no inhibition of MAP2K or other MAP3K family members. Induces apoptosis following TNF-α stimulation in in vitro models of rheumatoid arthritis and metastatic breast cancer.Specifications
| N1-(1-Propyl-1 H-benzimidazol-2-yl)-1,3-benzenedicarboxamide | |
| Other Kinase Inhibitors | |
| 0.98 |
| 1111556-37-6 | |
| C18H18N4O2 |
Safety and Handling
Recommended Storage : Store at -20°C
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