Takinib, MedChemExpress

MedChemExpress Takinib (EDHS-206) is an orally active and selective TAK1 inhibitor (IC50=9.5 nM), more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively.

Product Code	Brand	Quantity
16496577	Medchem Express HY-103490	5 mg
16474886	Medchem Express HY-103490	100 mg
16460227	Medchem Express HY-103490	50 mg
16433858	Medchem Express HY-103490	10 mg

Description

Takinib is an inhibitor of autophosphorylated TAK1 that non-competitively binds within the ATP binding pocket. Takinib induces apoptosis following TNFα stimulation in cell models of rheumatoid arthritis and metastatic breast cancer. Takinib is also a P. falciparum protein kinase 9 (PfPK9) inhibitor (KD(app) of 0.46 μM).

Specifications

• Chemical Name or Material: Takinib
• CAS: 1111556-37-6
• Purity Grade Notes: Research
• For Use With (Application): Cancer-Kinase/protease
• Solubility Information: DMSO : 50 mg/mL (155.11 mM; Need ultrasonic)
• Molecular Weight (g/mol): 322.36
• Percent Purity: 99.15%

• Physical Form: Solid
• Color: White
• Molecular Formula: C₁₈H₁₈N₄O₂
• Synonym: EDHS-206
• SMILES: CCCN1C2=CC=CC=C2N=C1NC(C3=CC(C(N)=O)=CC=C3)=O
• Formula Weight: 322.36
• Grade: Research

Safety and Handling

missing translation for 'shelfLife' : Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month

Recommended Storage : Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month

Research purposes only