Takinib, MedChemExpress

Artikelnummer. 16433858

Marke: Medchem Express HY103490

Beschreibung

MedChemExpress Takinib (EDHS-206) is an orally active and selective TAK1 inhibitor (IC50=9.5 nM), more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively.

Takinib is an inhibitor of autophosphorylated TAK1 that non-competitively binds within the ATP binding pocket. Takinib induces apoptosis following TNFα stimulation in cell models of rheumatoid arthritis and metastatic breast cancer. Takinib is also a P. falciparum protein kinase 9 (PfPK9) inhibitor (KD(app) of 0.46 μM).

Spezifikation

• Chemical Name or Material: Takinib
• Physical Form: Solid
• CAS: 1111556-37-6
• Color: White
• Quantity: 10 mg
• Purity Grade Notes: Research
• Molecular Formula: C₁₈H₁₈N₄O₂
• For Use With (Application): Cancer-Kinase/protease
• Synonym: EDHS-206
• Solubility Information: DMSO : 50 mg/mL (155.11 mM; Need ultrasonic)
• SMILES: CCCN1C2=CC=CC=C2N=C1NC(C3=CC(C(N)=O)=CC=C3)=O
• Molecular Weight (g/mol): 322.36
• Formula Weight: 322.36
• Percent Purity: 99.15%
• Grade: Research

Research purposes only