Invitrogen™ TACR3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5102108

Product Code. 16628584

Description

Antibody detects endogenous levels of total NK3R.

The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.

Specifications

• Antigen: TACR3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tacr3
• Gene Alias: G protein-coupled receptor; HH11; neurokinin 3 receptor; Neurokinin B; neurokinin B receptor; neurokinin beta receptor; neuromedin K receptor; Neuromedin K receptor (Neurokinin B/Tachikin 3); neuromedin-K receptor; Nk3 receptor; NK-3 receptor; NK3R; NK-3R; NK3R TAC3R; Nkr; Nmkr; Nmk-r; TAC3R; TAC3RL; tachikin receptor 3; tachykinin receptor 3; Tacr3
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21338, 24808, 6870
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P16177, P29371, P47937
• Gene Symbols: Tacr3
• Immunogen: A synthesized peptide derived from human TACR3(Accession P29371), corresponding to amino acid residues Y401-S451.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG