Tocris Bioscience™ T3 CLK

Código de producto. 18754434

Marca: Tocris Bioscience™ 7570/10

Descripción

Potent and selective pan-CLK inhibitor; also inhibits DYRK1A/B

T3 CLK is a potent and selective pan CDC-like kinase (CLK) inhibitor (IC50 values are 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively). T3 CLK also inhibits DYRK1A/B (IC50 values are 230 nM and 260 nM for DYRK1B and DYRK1A, respectively in cellular assays). Exhibits dose-dependent alternative splicing effects in HCT116 colorectal cancer cells. T3 CLK is cell permeable, stable and non-toxic.

Especificaciones

• Chemical Name or Material: 4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide
• CAS: 2109805-56-1
• Quantity: 10 mg
• Target: Cdc2-like Kinase Inhibitors
• Molecular Formula: C₂₈H₃₀N₆O₂
• Purity: 0.98