T Cell Receptor Gamma/Delta Hamster, anti-Mouse, Biotin, Clone: GL3, STEMCELL Technologies

Hamster Monoclonal Antibody

Brand:  Stemcell Technologies 60104BT

Product Code. 17199021

Description

• The GL3 antibody reacts with the δ chain of the murine T cell receptor γ/δ (TCRγ/δ or TCR gamma/delta), a subtype of the TCR involved in the recognition of both peptide and lipid antigens
• TCRγ/δ comprises a heterodimer (∼ 80 kDa in humans) of disulfide-linked γ and δ subunits that associates with CD3 on the cell surface
• It is a member of the immunoglobulin superfamily
• TCRγ/δ is expressed on a subpopulation of T cells in the circulation but may be found on up to 50% of the T cells in epithelial cell-rich tissues
• These cells have roles in oral and tumor-associated tolerance as well as autoimmune disease and have been described as a link between the adaptive and innate immune responses
• Once activated, they secrete effector cytokines in a subtype- and context-specific manner
• Most γ/δ T cells are CD4-/CD8-, though some express CD8
• The GL3 antibody recognizes an epitope in the constant region of the δ chain and can reportedly activate TCRγ/δ+ cells

Specifications

• Antigen: T Cell Receptor Gamma/Delta
• Classification: Monoclonal
• Conjugate: Biotin
• Quantity: 500 μg
• Target Species: Mouse
• Cell Type: T Cells, T Cells, Other Subsets

• Applications: Immunohistochemistry, Flow Cytometry, Immunofluorescence, Functional Assay, Blocking Assay
• Clone: GL3
• Host Species: Hamster
• Primary or Secondary: Primary
• Isotype: IgG2 κ