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Invitrogen™ SYPL2 Polyclonal Antibody

Product Code. 12848922
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12848922 100 μg 100µg
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Product Code. 12848922 Supplier Invitrogen™ Supplier No. PA520776

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human spleen tissue lysate. PA5-20776 can be used with blocking peptide PEP-0890.

SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SYPL2
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SYPL2
Gene Accession No. O89104, Q5VXT5
Gene Alias AI552439; MG29; mitsugumin 29; mitsugumin29; mitsugumin-29; synaptophysin like 2; synaptophysin-like 2; synaptophysin-like protein 2; Sypl2; UNQ6348
Gene Symbols SYPL2
Host Species Rabbit
Immunogen A 15 amino acid peptide near the carboxy terminus of human SYPL.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17306, 284612, 362018
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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