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Invitrogen™ SYNPO2 Polyclonal Antibody

Product Code. 12839202
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12839202 100 μg 100µg
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Product Code. 12839202 Supplier Invitrogen™ Supplier No. PA521055

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human skeletal muscle tissue lysate. PA5-21055 can be used with blocking peptide PEP-1169.

SYNPO2 was initially identified as myopodin, a member of the synaptopodin family that contains one PPXY motif and multiple PXXP motifs. It colocalizes with alpha-actinin and is found at the Z-disc and during stress conditions will translocate to the nucleus, suggesting that it is part of signaling pathways in addition to its function as a structural protein. SYNPO2 has been shown to bind to calmodulin, alpha-actinin, and smooth muscle myosin and will stimulate actin polymerization in a calmodulin dependent manner, consistent with its proposed role in organizing the cytoskeleton. While deletion of SYNPO2 has been reported to be highly correlated with the invasiveness of prostate cancers, other reports suggest that down-regulation of SYNPO2 reduces the invasiveness and motility of prostate cancer cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SYNPO2
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SYNPO2
Gene Accession No. Q91YE8, Q9UMS6
Gene Alias 1110069I04Rik; 2310068J10Rik; 9530006G20Rik; AI848603; genethonin 2; Genethonin-2; Myo; Myopodin; mypodin; RGD1564779; synaptopodin 2; synaptopodin-2; Synpo2
Gene Symbols SYNPO2
Host Species Rabbit
Immunogen A 20 amino acid peptide near the amino terminus of human SYNPO2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 118449, 171024
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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