Invitrogen™ SUV420H1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA566611

Product Code. 15969304

Description

Immunogen sequence: DQGEHSGTVGV PVSYTDCAPS PVGCSVVTSD SFKTKDSFRT AKSKKKRRIT RYDAQLILEN NSGIPKLTLR Highest antigen sequence identity to the following orthologs - mouse 86%, rat 87%.

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Plays a role in myogenesis by regulating the expression of target genes, such as EID3.

Specifications

• Antigen: SUV420H1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KMT5B
• Gene Alias: [histone H4]-lysine20 N-methyltransferase KMT5B; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; AA117471; C630029K18Rik; CGI85; CGI-85; histone-lysine N-methyltransferase KMT5B; histone-lysine N-methyltransferase SUV420H1; Kmt5b; lysine (K)-specific methyltransferase 5B; lysine methyltransferase 5B; lysine N-methyltransferase 5B; Lysine-specific methyltransferase 5B; MGC118906; MGC118909; MGC21161; MGC703; si:dkey-12e7.2; Su(var)4-20 homolog 1; suppressor of variegation 4-20 homolog 1; suppressor of variegation 4-20 homolog 1 (Drosophila); suppressor of variegation 4-20 protein-like 1; SUV420; SUV420H1; suv4-20h1; Unknown (protein for MGC:137299); wu:fb97g06; wu:fi57g03; zgc:103527
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51111
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q4FZB7
• Gene Symbols: KMT5B
• Immunogen: Recombinant Human SUV420H1. Recombinant protein control fragment (Product #RP-107271).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG