Invitrogen™ SUR1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA550836

Product Code. 15644765

Description

The antibody detects endogenous levels of total ABCC8 protein.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.

Specifications

• Antigen: SUR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ABCC8
• Gene Alias: ABC36; ABCC8; AM60008PU-N; ATP binding cassette subfamily C member 8; ATP-binding cassette sub-family C member 8; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette, subfamily C (CFTR/MRP), member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; D930031B21Rik; HHF1; HI; HRINS; LOW QUALITY PROTEIN: ATP-binding cassette sub-family C member 8; MRP8; PH SUR1; PHHI; sulfonylurea receptor; sulfonylurea receptor (hyperinsulinemia); sulfonylurea receptor 1; sulfonylurea receptor subunit 1; sulphonylurea receptor 1; SUR; SUR1; SUR1 protein; SUR1delta2; TNDM2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6833
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 2.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q09428
• Gene Symbols: ABCC8
• Immunogen: Synthetic peptide corresponding to residues near the C terminal (aa 1567-1581) of human ATP-binding cassette, sub-family C (CFTR/MRP), member 8.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG