Invitrogen™ SUR1 Monoclonal Antibody (N289/16)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA527660

Product Code. 16332174

Description

1 μg/mL of MA5-27660 was sufficient for detection of SUR1 in 20 μg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 160kDa. Does not cross-react with SUR2B. This antibody was formerly sold as clone S289-16.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.

Specifications

• Antigen: SUR1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q09428, Q09429
• Gene Symbols: ABCC8
• Immunogen: Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Hamster
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
• Clone: N289/16
• Conjugate: Unconjugated
• Gene: ABCC8
• Gene Alias: ABC36; ABCC8; AM60008PU-N; ATP binding cassette subfamily C member 8; ATP-binding cassette sub-family C member 8; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette, subfamily C (CFTR/MRP), member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; D930031B21Rik; HHF1; HI; HRINS; LOW QUALITY PROTEIN: ATP-binding cassette sub-family C member 8; MRP8; PH SUR1; PHHI; sulfonylurea receptor; sulfonylurea receptor (hyperinsulinemia); sulfonylurea receptor 1; sulfonylurea receptor subunit 1; sulphonylurea receptor 1; SUR; SUR1; SUR1 protein; SUR1delta2; TNDM2
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 100764394, 20927, 25559, 6833
• Content And Storage: -20°C
• Form: Liquid