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Sur-8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

£130.00 - £339.00

Specifications

Antigen Sur-8
Concentration 0.33 mg/mL
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16877474
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Proteintech
17561-1-AP-20UL
20 μL
£130.00
20µL
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Estimated Shipment: 02-05-2024
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16867474
View Documents Promotion Details
Proteintech
17561-1-AP-150UL
150 μL
£339.00
150µL
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Estimated Shipment: 02-05-2024
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Description

Description

SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noo-like syndrome with loose anagen hair.
Specifications

Specifications

Sur-8
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Rabbit
Human, Rat, Mouse
O88520, Q6AYI5, Q9UQ13
309548, 56392, 8036
Sur-8 Fusion Protein Ag11754
Primary
-20°C
SHOC2
0.33 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
KIAA0862, Protein soc 2 homolog, Protein sur 8 homolog, SHOC2, SIAA0862, SOC 2, SOC2, SUR 8, SUR8, sur-8
Shoc2
IgG
Antigen Affinity Chromatography
Antibody
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SDS
Documents

Documents

Product Certifications