Invitrogen™ SUPV3L1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA558364

Product Code. 15756241

Description

Immunogen sequence: GMGLNLSIRR IIFYSLIKPS INEKGERELE PITTSQALQI AGRAGRFSSR FKEGEVTTMN HEDLSLLKEI LKRPVDPIRA AGLHPTAE Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 91%.

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. [UniProt].

Specifications

• Antigen: SUPV3L1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SUPV3L1
• Gene Alias: 6330443E10Rik; ATP-dependent RNA helicase SUPV3L1, mitochondrial; Suppressor of var1 3-like protein 1; suppressor of var1, 3-like 1; suppressor of var1, 3-like 1 (S. cerevisiae); suppressor of var1, 3-like 1(SUV3); SUPV3L1; SUV3; Suv3 like RNA helicase; Suv3l1; SUV3-like helicase; SUV3-like protein 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6832
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IYB8
• Gene Symbols: SUPV3L1
• Immunogen: Recombinant protein corresponding to Human SUPV3L1. Recombinant protein control fragment (Product #RP-97137).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG