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STEMCELL Technologies STO-609 (Acetate)

Product Code. 17150282
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 17150282

Brand: STEMCELL Technologies 73862

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Description

Calcium signaling inhibitor; Inhibits calcium/calmodulin-dependent kinase kinases (CaMKKs)

  • STO-609 is a cell-permeable, selective inhibitor of ATP-competitive calcium/calmodulin-dependent kinase kinases (CaMKK)
  • STO-609 inhibits the activities of recombinant isoforms CaMKKα (Ki = 80 ng/mL) and CaMKKβ (Ki = 15 ng/mL) and also inhibits their autophosphorylation (Kukimoto-Niino et al.; Tokumitsu et al.) STO-609 reduces thrombin-induced nuclear localization of NF-κB activation in endothelial cells (Bair et al.) This product is supplied as the acetate salt form of the molecule
  • Stimulates osteoblast formation and inhibits osteoclast differentiation in mouse mesenchymal stem cells, and reverses age-associated decline in bone mass (Cary et al.; Pritchard et al.)
  • Decreases in vitro growth of human hepatic cancer cell lines, and decreases tumor burden in mouse hepatic tumor model (Lin et al.)

Specifications

CAS 1173022-21-3
Quantity 10 mg
Molecular Formula C19H10N2O3 · C2H4O2
Purity ≥98%
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