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  6. Invitrogen™ STING Recombinant Rabbit Monoclonal Antibody (K01_2J33)

Invitrogen™ STING Recombinant Rabbit Monoclonal Antibody (K01_2J33)
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Product Code. 30827873
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30825021 50 μL
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Product Code. 30827873 Supplier Invitrogen™ Supplier No. MA563873
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Estimated Shipment: 25-09-2026
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: QYSQAGFSRE DRLEQAKLFC RTLEDILADA PESQNNCRLI AYQEPADDSS FSLSQEVLRH LRQEEKEEVT VGSLKTSAVP STSTMSQEPE LLISGMEKPL PLRTD Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 74%, Pig - 81%, Cynomolgus monkey - 93%.

STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen STING
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone K01_2J33
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 150mM NaCl, 0.05% BSA, 40% glycerol and 0.01% sodium azide; pH 7.4
Gene TMEM173
Gene Accession No. F1M391, Q86WV6
Gene Alias 2610307O08Rik; endoplasmic reticulum IFN stimulator; endoplasmic reticulum interferon stimulator; ERIS; hMITA; hSTING; hypothetical LOC533661; mediator of IRF3 activation; Mita; mitochondrial mediator of IRF3 activation; mitochondrial transmembrane protein 173; MMITA; Mpys; mSTING; NET23; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; poSTING; RGD1562552; rSTING; SAVI; Stimulator of interferon genes protein; stimulator of interferon response cGAMP interactor 1; STING; STING1; tm173; Tmem173; Transmembrane protein 173
Gene Symbols TMEM173
Host Species Rabbit
Immunogen Recombinant protein of human TMEM173 (aa 273-377).
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 340061, 498840
Target Species Human, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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